Article

Differential Akt Signaling Induced by Tumstatin and Endostatin in Human Endothelial Cells

2026-06-12

Abstract excerpt

Tumstatin and Endostatin are endogenous extracellular matrix-derived inhibitors of angiogenesis generated from the non-collagenous domains of type IV and type XVIII collagens, respectively. Although both molecules suppress angiogenesis and tumor growth in vivo, previous studies demonstrated that they engage distinct endothelial integrin receptors and activate different intracellular signaling pathways. In particul...

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Literature Corpus work: 26451a33-8f90-5735-a186-e4cff33b4543
DOI: 10.64898/2026.06.09.731223

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