Article

Cytolethal Distending Toxin Enhances <i>Escherichia coli</i> Urinary Tract Infection

2026-02-10

Abstract excerpt

Cytolethal distending toxin (CDT) is a virulence factor produced by several gram-negative bacteria, including Escherichia coli , the most prevalent etiological agent of urinary tract infections (UTI). CDT causes DNA damage in eukaryotic cells, impairing host defenses by disrupting epithelial barriers, suppressing acquired immunity, and promoting pro-inflammatory responses. E. coli strains encoding CDT have been...

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Literature Corpus work: 261777a5-e83e-54d1-b212-7c56526ab5d7
DOI: 10.64898/2026.02.09.704878

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