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Article

Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation.

Neuron - 22 Mar 2012

Harwell Corey C, Parker Philip R L, Gee Steven M, Okada Ami, McConnell Susan K, Kreitzer Anatol C, Kriegstein Arnold R

Abstract excerpt

VIDEO ABSTRACT: The precise connectivity of inputs and outputs is critical for cerebral cortex function; however, the cellular mechanisms that establish these connections are poorly understood. Here, we show that the secreted molecule Sonic Hedgehog (Shh) is involved in synapse formation of a specific cortical circuit. Shh is expressed in layer V corticofugal projection neurons and the Shh receptor, Brother of...

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Identifiers

PMID: 22445340
DOI: 10.1016/j.neuron.2012.02.009
PMCID: PMC3551478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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