Article

Distinguishing Pseudotransduction and True Transduction Enables Characterization and Bioengineering of Extracellular Vesicle-Adeno-Associated Virus Vectors

2025-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Adeno-associated virus (AAV) gene therapies have achieved some clinical success, with multiple products reaching regulatory approval. Encapsulation of AAV vectors within engineered extracellular vesicles (EVs) is an emerging strategy which could help overcome challenges including pre-existing anti-capsid immunity and the need for controlling targeting and tropism. To guide the development of EV-...

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Literature Corpus work: 25e2e398-88ce-53d5-97a4-c0af547d54b9
DOI: 10.1101/2025.07.02.662894

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