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Article

Extracellular vesicles enhance pulmonary transduction of stably associated adeno‐associated virus following intratracheal administration

1 Jun 2023

Abstract excerpt

Adeno-associated virus (AAV) vector has shown multiple clinical breakthroughs, but its clinical implementation in inhaled gene therapy remains elusive due to difficulty in transducing lung airway cells. We demonstrate here AAV serotype 6 (AAV6) associated with extracellular vesicles (EVs) and secreted from vector-producing HEK-293 cells during vector preparation (EVAAV6) as a safe and highly efficacious gene...

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PMID: 37272896
DOI: 10.1002/jev2.12324

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