Article

A Genome-wide Survey of Mutations in the Jurkat Cell Line

2017-03-18

Abstract excerpt

The Jurkat cell line has an extensive history as a model of T cell signaling. But at the turn of the 21st century, some irregularities were observed in Jurkat’s expression of central regulators of T cell receptor signaling, which raised doubts about how closely the cell line paralleled normal human T cells. While numerous expression deficiencies have been described in Jurkat, genetic explanations have only been pr...

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Literature Corpus work: 2553352d-6128-5e06-9970-f241e6a74454
DOI: 10.1101/118117

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