Discovering mechanisms of human genetic variation and controlling cell states at scale.

Abstract excerpt

Population-scale sequencing efforts have catalogued substantial genetic variation in humans such that variant discovery dramatically outpaces interpretation. We discuss how single-cell sequencing is poised to reveal genetic mechanisms at a rate that may soon approach that of variant discovery. The functional genomics toolkit is sufficiently modular to systematically profile almost any type of variation within...

Topics

• Humans
• Genetic Variation
• Single-Cell Analysis
• Genomics
• Genome, Human
• Phenotype