Article

Enhanced viral infectivity and reduced interferon production are associated with high pathogenicity for influenza viruses

2022-07-29

Abstract excerpt

Epidemiological and clinical evidence indicates that humans infected with the 1918 pandemic influenza virus and highly pathogenic avian H5N1 influenza viruses often displayed severe lung pathology. High viral load and extensive infiltration of macrophages are the hallmarks of highly pathogenic (HP) influenza viral infections. However, it remains unclear what biological mechanisms primarily determine the observed d...

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Literature Corpus work: 2516d164-b9f7-5c29-9534-cf54e8e0cd68
DOI: 10.1101/2022.07.29.501947

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