Article
Effect of 1918 PB1-F2 Expression on Influenza A Virus Infection Kinetics
17 Feb 2011
Abstract excerpt
Relatively little is known about the viral factors contributing to the lethality of the 1918 pandemic, although its unparalleled virulence was likely due in part to the newly discovered PB1-F2 protein. This protein, while unnecessary for replication, increases apoptosis in monocytes, alters viral polymerase activity in vitro, enhances inflammation and increases secondary pneumonia in vivo. However, the effects...
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