Article

Neutralizing Antibodies Reveal Cryptic Vulnerabilities and Interdomain Crosstalk in the Porcine Deltacoronavirus Spike

2024-01-09

Abstract excerpt

<title>Abstract</title> <p>Porcine deltacoronavirus (PDCoV) is an emerging enteric pathogen in pigs that has recently been detected in humans. Despite this zoonotic concern, the antigenic structure of PDCoV remains unknown. The virus relies on its spike (S) protein for cell entry, making it a prime target for neutralizing antibodies. Here we generated and characterized a set of neutralizing antibodies targeting t...

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Literature Corpus work: 24fddab4-6ab2-590e-9a44-7a8fea3f0b95
DOI: 10.21203/rs.3.rs-3726585/v1

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