Roles of Two Major Domains of the Porcine Deltacoronavirus S1 Subunit in Receptor Binding and Neutralization.

doi:10.1128/JVI.01118-21

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Article

Roles of Two Major Domains of the Porcine Deltacoronavirus S1 Subunit in Receptor Binding and Neutralization.

Journal of virology - 23 Nov 2021

Liu Yan, Wang Bin, Liang Qi-Zhang, Shi Fang-Shu, Ji Chun-Miao, Yang Xiao-Lian, Yang Yong-Le, Qin Pan, Chen Ruiai, Huang Yao-Wei

Abstract excerpt

Determination of the mechanisms of interspecies transmission is of great significance for the prevention of epidemic diseases caused by emerging coronaviruses (CoVs). Recently, porcine deltacoronavirus (PDCoV) was shown to exhibit broad host cell range mediated by surface expression of aminopeptidase N (APN), and humans have been reported to be at risk of PDCoV infection. In the present study, we first...

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PMID: 34549985
DOI: 10.1128/JVI.01118-21
PMCID: PMC8610578

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