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Structures of a deltacoronavirus spike protein bound to porcine and human receptors

18 Mar 2022

Abstract excerpt

Porcine deltacoronavirus (PDCoV) can experimentally infect a variety of animals. Human infection by PDCoV has also been reported. Consistently, PDCoV can use aminopeptidase N (APN) from different host species as receptors to enter cells. To understand this broad receptor usage and interspecies transmission of PDCoV, we determined the crystal structures of the receptor binding domain (RBD) of PDCoV spike protein...

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Identifiers

PMID: 35304871
DOI: 10.1038/s41467-022-29062-5

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