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Phosphoregulation of the septin cytoskeleton in neuronal development and disease

20 Sept 2022

Abstract excerpt

Septins are highly conserved GTP-binding proteins that oligomerize and form higher order structures. The septin cytoskeleton plays an important role in cellular organization, intracellular transport, and cytokinesis. Kinase-mediated phosphorylation of septins regulates various aspects of their function, localization, and dynamics. Septins are enriched in the mammalian nervous system where they contribute to...

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PMID: 36127729
DOI: 10.1002/cm.21728

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