Article

Pathway centrality in protein interaction networks identifies functional mediators of pulmonary disease

2017-08-03

Abstract excerpt

Identification of functional pathways mediating molecular responses may lead to better understanding of disease processes and suggest new therapeutic approaches. We introduce a method to detect such mediating functions using topological properties of protein-protein interaction networks. We introduce the concept of pathway centrality, a measure of communication between disease genes and differentially expressed ge...

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Literature Corpus work: 83bc3f93-8045-5c52-8589-91c58aa92a67
DOI: 10.1101/171942

Open publication

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