Article

singIST: an integrative method for comparative single-cell transcriptomics between disease models and humans

2024-12-22

Abstract excerpt

<h4>Motivation</h4> Disease models serve as fundamental tools in drug discovery and early-stage drug development. However, these models are not a perfect reflection of human disease, and selecting a suitable model can be challenging. Existing computational approaches for molecular validation of pathophysiological resemblance to human conditions at single-cell resolution remain limited. Although quantitative compu...

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Literature Corpus work: 2462408c-608a-55f2-b79c-4f4e0d660a8f
DOI: 10.1101/2024.12.20.629624

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