Pathway-based similarity measurement to quantify transcriptomics similarity between human tissues and preclinical models

Abstract excerpt

Accurate clinical translation of preclinical research remains challenging, primarily due to species-specific differences and disease and patient heterogeneity. An important recent advancement has been development of microphysiological systems that consist of multiple human cell types that recapitulate key characteristics of their respective human systems, allowing essential physiologic processes to be accurately a...

Topics

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• Clinical Trials, Phase III as Topic
• Gene Expression Profiling
• Gene Regulatory Networks
• Genetic Predisposition to Disease
• Liver physiology and pathology
• Molecular Targeted Therapy
• Oligonucleotide Array Sequence Analysis
• Pancreatic function and diabetes

Identifiers and source

Literature Corpus work

375c35d5-a78b-5a28-92b7-d88d96ab2cf7

DOI

10.1101/2024.04.13.589385