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Article

The Nrf2 induction prevents ferroptosis in Friedreich's Ataxia

5 Nov 2020

Abstract excerpt

Ferroptosis is an iron-dependent cell death caused by impaired glutathione metabolism, lipid peroxidation and mitochondrial failure. Emerging evidences report a role for ferroptosis in Friedreich's Ataxia (FRDA), a neurodegenerative disease caused by the decreased expression of the mitochondrial protein frataxin. Nrf2 signalling is implicated in many molecular aspects of ferroptosis, by upstream regulating...

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PMID: 33197769
DOI: 10.1016/j.redox.2020.101791

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