Article

A-to-I edited miR-411-5p targets MET and promotes TKI response in NSCLC

2022-09-06

Abstract excerpt

<title>Abstract</title> <p>The epidermal growth factor receptor (EGFR) is a tyrosine kinase receptor (TKR) frequently mutated in lung cancer. Despite initially favorable clinical responses of non-small cell lung cancer (NSCLC) patients harboring an EGFR mutation to treatment with tyrosine kinase inhibitors (TKIs), rapid resistance occurs mainly because of genetic alterations, including amplification of the hepato...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23c0bba1-b151-5882-85e6-8aecfd1f3097
DOI: 10.21203/rs.3.rs-1957094/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A-to-I edited miR-411-5p targets MET and promotes TKI response in NSCLCDOI 10.21203/rs.3.rs-1957094/v1Read

Adenosine-to-inosine RNA editing in cancer: molecular mechanisms and downstream targetsSemantic proximity Read

The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.Semantic proximity Read

Somatic A-to-I RNA-edited RHOA isoform 2 specific-R176G mutation promotes tumor progression in lung adenocarcinoma.Semantic proximity Read

Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma.Semantic proximity Read

A multi-omics approach to identify the impact of miR-411ed on NSCLC TKI resistanceSemantic proximity Read

MicroRNA-200a Targets EGFR and c-Met to Inhibit Migration, Invasion, and Gefitinib Resistance in Non-Small Cell Lung CancerSemantic proximity Read

Comprehensive Characterization of RNA Editing in Primary Gastric Adenocarcinoma through RNA-seq Data AnalysisSemantic proximity Read

ADAT2/3-mediated tRNA editing promotes cancer cell growth and tumorigenicitySemantic proximity Read

RNA Editing Alters miRNA Function in Chronic Lymphocytic LeukemiaSemantic proximity Read

APOBEC-1-mediated RNA editing.Semantic proximity Read

Circular RNA-Encoded MET Variant Is a Targetable Factor in GlioblastomaSemantic proximity Read

MiREDiBase: a manually curated database of validated and putative editing events in microRNAsSemantic proximity Read