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Article

The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma.

Life sciences - 1 May 2022

Hua Hui, Zeng Jiajia, Xing Haixin, He Yuxin, Han Linyu, Zhang Nasha, Yang Ming

Abstract excerpt

AIMS: The adenosine-to-inosine (A-to-I) RNA editing controlled by the editing genes are known to diversify transcripts in human. Aberrant A-to-I editing due to dysregulation of the editing genes are involved in cancer development. However, it is still largely unclear how single nucleotide polymorphisms (SNPs) in the A-to-I editing genes confer to recurrence and/or drug resistance of epidermal growth factor...

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Identifiers

PMID: 35202641
DOI: 10.1016/j.lfs.2022.120408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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