Article

Comprehensive transcriptomic analysis shows disturbed calcium homeostasis and deregulation of T lymphocyte apoptosis in inclusion body myositis

2021-07-01

Abstract excerpt

<h4>Objective</h4> Inclusion body myositis (IBM) has an unclear molecular etiology due to the co-existence of characteristic cytotoxic T-cell activity and degeneration of muscle fibers. Using in-depth gene expression and splicing studies, we aimed at understanding the different components of the molecular pathomechanisms in IBM. <h4>Methods</h4> We performed RNA-seq on RNA extracted from skeletal muscle biopsies...

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Literature Corpus work: 05dc1e22-f35b-544d-b273-6f8cca5c6797
DOI: 10.1101/2021.06.30.450477

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