Article

Identification of locally activated spindle-associated proteins in oocytes uncovers a phosphatase-driven mechanism

2025-05-19

Abstract excerpt

The meiotic spindle forms only around the chromosomes in oocytes, despite the exceptionally large volume of the cytoplasm. This spatial restriction is likely to be governed by local activation of key microtubule regulators around the chromosomes in oocytes, but the identities of these microtubule regulators and the mechanisms remain unclear. To address this, we developed a novel assay to visualise spatial regulati...

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Literature Corpus work: 2398ef48-8bab-5438-90cc-bfcab3aa8850
DOI: 10.1101/2025.05.19.654801

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