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Article

A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes.

Biology open - 7 May 2020

Vorster Paul J, Goetsch Paul, Wijeratne Tilini U, Guiley Keelan Z, Andrejka Laura, Tripathi Sarvind, Larson Braden J, Rubin Seth M, Strome Susan, Lipsick Joseph S

Abstract excerpt

The five-protein MuvB core complex is highly conserved in animals. This nuclear complex interacts with RB-family tumor suppressor proteins and E2F-DP transcription factors to form DREAM complexes that repress genes that regulate cell cycle progression and cell fate. The MuvB core complex also interacts with Myb family oncoproteins to form the Myb-MuvB complexes that activate many of the same genes. We show that...

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PMID: 32295830
DOI: 10.1242/bio.051508
PMCID: PMC7225089

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A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes.PMID 32295830Read ↗

A Long Lost Key Opens an Ancient Lock: <i>Drosophila</i> Myb Causes a Synthetic Multivulval Phenotype in NematodesSemantic proximity Read ↗

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DREAM Interrupted: Severing LIN-35-MuvB association in <i>Caenorhabditis elegans</i> impairs DREAM function but not its chromatin localizationSemantic proximity Read ↗

DREAM interrupted: severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization.Semantic proximity Read ↗

Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.Semantic proximity Read ↗

gon-14 functions with class B and class C synthetic multivulva genes to control larval growth in Caenorhabditis elegans.Semantic proximity Read ↗

Caenorhabditis elegans lin-13, a member of the LIN-35 Rb class of genes involved in vulval development, encodes a protein with zinc fingers and an LXCXE motif.Semantic proximity Read ↗

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Loss of the Caenorhabditis elegans pocket protein LIN-35 reveals MuvB's innate function as the repressor of DREAM target genes.Semantic proximity Read ↗

LIN-15B promotes enrichment of H3K9me2 on the promoters of a subset of germline genes that are repressed in somatic cells in C. elegansSemantic proximity Read ↗

Diverse chromatin remodeling genes antagonize the Rb-involved SynMuv pathways in C. elegans.Semantic proximity Read ↗

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