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ALDH2 regulates mesenchymal stem cell senescence via modulation of mitochondrial homeostasis

4 Aug 2024

Abstract excerpt

Although mitochondrial aldehyde dehydrogenase 2 (ALDH2) is involved in aging and aging-related diseases, its role in the regulation of human mesenchymal stem cell (MSC) senescence has not been investigated. This study aimed to determine the role of ALDH2 in regulating MSC senescence and illustrate the potential mechanisms. MSCs were isolated from young (YMSCs) and aged donors (AMSCs). Senescence-associated...

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PMID: 39097205
DOI: 10.1016/j.freeradbiomed.2024.07.040

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