Article

Tumor-promoting EGFRvIII/c-Jun/IGFBP3 signaling circuit is induced by TGF-β-EGFRvIII transactivation in glioblastoma

2022-07-14

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor with a median survival of less than one year. EGFR and EGFRvIII amplification are significant genetic signature in GBM. Currently, the treatment targeting EGFRvIII cannot effectively prolong the survival of patients. TGF-β is secreted by a variety of cells in the GBM immunosuppressive microenvironment, mediating the malignant progressio...

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Literature Corpus work: 230a58c2-f683-5cef-8e02-a309198a25ac
DOI: 10.21203/rs.3.rs-1712816/v1

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