Article

Convergent effects of neurodevelopmental disorder-associated variants at mitochondria

2026-02-27

Abstract excerpt

Investigations into the molecular pathogenesis of clinically defined neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASD) and schizophrenia (SCZ) have produced evidence implicating dysfunctional mitochondrial metabolism. However, the functional connection between risk variants and mitochondrial proteins largely remains unclear. We tested the hypothesis that proteins encoded by NDD-associat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 23038466-bb0e-57c7-926b-5831034870a7
DOI: 10.64898/2026.02.26.708316

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Convergent effects of neurodevelopmental disorder-associated variants at mitochondriaDOI 10.64898/2026.02.26.708316Read

Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletionSemantic proximity Read

Integrative synaptosome multi-omics reveals disrupted synapse organization and localized cryptic transcripts in <i>C9ORF72</i> -Frontotemporal DementiaSemantic proximity Read

Tissue and cell-type specific molecular and functional signatures of 16p11.2 reciprocal genomic disorder across mouse brain and human neuronal modelsSemantic proximity Read

Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Semantic proximity Read

Convergent and distributed effects of the schizophrenia-associated 3q29 deletion on the human neural transcriptomeSemantic proximity Read

Association between de novo variants of nuclear-encoded mitochondrial-related genes and undiagnosed developmental disorder and autism.Semantic proximity Read

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and BehaviorSemantic proximity Read

Transcriptomic signatures of nine high-risk neuropsychiatric copy number variants in human brain cellsSemantic proximity Read

Convergence and divergence of molecular phenotypes in iPSC-derived models of 16p11.2 and 22q11.2 reciprocal copy number variants.Semantic proximity Read

Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome.Semantic proximity Read

Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation DataSemantic proximity Read

Convergent Canonical Pathways in Autism Spectrum Disorder from Proteomic, Transcriptomic and DNA Methylation Data.Semantic proximity Read