Article

TK216 targets microtubules in Ewing sarcoma cells

2021-11-19

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EWS) is a pediatric malignancy driven by the EWSR1-FLI1 fusion protein formed by the chromosomal translocation t(11;22). The small molecule TK216 was developed as a first-in-class direct EWSR1-FLI1 inhibitor and is in phase II clinical trials in combination with vincristine for EWS patients. However, TK216 exhibits anti-cancer activity against cancer cell lines and xenografts that...

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Literature Corpus work: 22ff73e5-07ec-53e7-a958-5e9bc270aa6b
DOI: 10.1101/2021.11.19.469182

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