Article

Nanoparticle-mediated Targeting of the Fusion Gene <i>RUNX1/ETO</i> in t(8;21)-positive Acute Myeloid Leukaemia

2022-09-21

Abstract excerpt

A hallmark of acute myeloid leukaemias (AMLs) are chromosomal rearrangements that give rise to novel leukaemia-specific fusion genes. Most of these fusion genes are both initiating and driving events in AML and therefore constitute ideal therapeutic targets but are challenging to target by conventional drug development. siRNAs are frequently used for the specific suppression of fusion gene expression but require s...

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Literature Corpus work: bae82196-b54f-5ee0-b23b-a4723dd51c12
DOI: 10.1101/2022.09.21.508893

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