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Article

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

2023-02-27

Abstract excerpt

Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (M pro ) variants and a robust cell-based assay are used to compare the resistance profiles of nirmatrelvir, ensitrelvir, and FB2001. The results reveal distinct resistance mechanisms (“fingerprints”) and indicate that these next-generation drugs h...

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Identifiers and source

Literature Corpus work
22ed41de-77ac-571a-808b-5931e5df3f80
DOI
10.1101/2023.02.25.530000
Open publication

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Rapid resistance profiling of SARS-CoV-2 protease inhibitorsDOI 10.1101/2023.02.25.530000
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