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An Investigation of Nirmatrelvir (Paxlovid) Resistance in SARS-CoV-2 Mpro

8 Oct 2024

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide The high throughput YESS 2.0 platform was used to screen a large library of SARS-CoV-2 M pro variants in the presence of nirmatrelvir. Of the 100 individual most prevalent mutations identified in the screen and reported here, the most common were E166V, L27V, N142S, A173V, and Y154N, along with their various combinations. In vitro analysis revealed that...

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PMID: 39712205
DOI: 10.1021/acsbiomedchemau.4c00045

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