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Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways

21 Nov 2008

Abstract excerpt

Mutations in the gene CLN3 are responsible for the neurodegenerative disorder juvenile neuronal ceroid lipofuscinosis or Batten disease. CLN3 encodes a multi-spanning and hydrophobic transmembrane protein whose function is unclear. As a consequence, the cell biology that underlies the pathology of the disease is not well understood. We have developed a genetic gain-of-function system in Drosophila to identify...

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PMID: 19028667
DOI: 10.1093/hmg/ddn396

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