Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of a cancer-associated mutation and multiple serine phosphorylation on poly(ADP-ribose) polymerase 2.

Biophysical journal - 15 Sept 2026

Hughes Bridget, Chatterjee Shubham, Ghafari Mozhdeh, Cisneros G Andrés

Abstract excerpt

Poly(ADP-ribose) polymerase 2 (PARP2) plays a crucial role in DNA repair. A common single-nucleotide polymorphism (SNP) in the PARP2 gene, rs3093921, has been associated with pancreatic cancer and marginal zone lymphoma. This SNP results in a missense mutation, D235G, in the PARP2 protein. PARP2 is also reported to undergo posttranslational modifications (PTMs), particularly phosphorylation at serine residues...

Read the complete abstract on PubMed

Topics

Poly(ADP-ribose) Polymerases
Serine
Phosphorylation
Molecular Dynamics Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Neoplasms

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 40734277
DOI: 10.1016/j.bpj.2025.07.025
PMCID: PMC12403910

Genes

PARP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 22 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of a cancer-associated mutation and multiple serine phosphorylation on poly(ADP-ribose) polymerase 2.PMID 40734277Read ↗

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damageSemantic proximity Read ↗

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 Inhibition.Semantic proximity Read ↗

Impact of a Cancer-Associated Mutation on Poly(ADP-ribose) Polymerase1 InhibitionSemantic proximity Read ↗

PARP1 Val762Ala polymorphism reduces enzymatic activity.Semantic proximity Read ↗

Characterization of the DNA dependent activation of human ARTD2/PARP2Semantic proximity Read ↗

A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activationSemantic proximity Read ↗

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation.Semantic proximity Read ↗

Updated protein domain annotation of the PARP protein family sheds new light on biological functionSemantic proximity Read ↗

Structural Basis of Detection and Signaling of DNA Single-Strand Breaks by Human PARP-1Semantic proximity Read ↗

HPF1 remodels the active site of PARP1 to enable the serine ADP-ribosylation of histonesSemantic proximity Read ↗

A site-specific analysis of the ADP-Ribosylome unveils Homogeneous DNA Damage-Induced Serine ADP-Ribosylation across wild-type and BRCA-mutant Breast Cancer cell linesSemantic proximity Read ↗

ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.