Article

Type I Interferon induces Keratinocytes Necroptosis via the ZBP1-MLKL Axis in Oral Lichen Planus

2025-11-17

Abstract excerpt

<title>Abstract</title> <p>Oral lichen planus (OLP) is a prevalent chronic inflammatory condition that affects the oral mucosa. Histologically, it is characterized by the liquefaction and degeneration of basal epithelial cells, indicating a disruption of the basal layer architecture, which may represent an early event in the disease’s pathogenesis. However, the molecular mechanisms underlying this epithelial dama...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22d82e68-671d-5244-9764-351e92f33544
DOI: 10.21203/rs.3.rs-7981446/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Type I Interferon induces Keratinocytes Necroptosis via the ZBP1-MLKL Axis in Oral Lichen PlanusDOI 10.21203/rs.3.rs-7981446/v1Read

Role of Efferocytosis in Oral Lichen PlanusSemantic proximity Read

Investigating the Role of Necroptosis in the Immunological Microenvironment of PeriodontitisSemantic proximity Read

IFNγ and TNFα Driven IRF1-Caspase 8 Dependent PANoptosis Promotes Keratinocyte Death in Psoriasis Independent of ZBP1Semantic proximity Read

Inflammation-related cytokines in oral lichen planus: an overview.Semantic proximity Read

Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivitySemantic proximity Read

Checkpoint inhibitor–induced lichen planus differs from spontaneous lichen planus on the clinical, histological, and gene expression levelSemantic proximity Read

IGF1 modulates lesional skin inflammation in checkpoint inhibitor-induced lichen planusSemantic proximity Read

B cells infiltration potentially responded better to systemic corticoids in oral lichen planus and oral lichenoid lesionsSemantic proximity Read

Multiomic Analysis Reveals an IFN-driven Cellular Landscape Effectively Targeted by Ruxolitinib in Hailey-Hailey DiseaseSemantic proximity Read

Oral Baricitinib in the Treatment of Cutaneous Lichen PlanusSemantic proximity Read

Interferon-γ regulates the function of mesenchymal stem cells from oral lichen planus via indoleamine 2,3-dioxygenase activity.Semantic proximity Read

Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+CD8+ T cellsSemantic proximity Read