Article

Transcriptomic Analysis of Radio-resistant A549 Cells Identify Stemness Gene Signature to Predict Radiotherapy Response in Lung Adenocarcinoma Patients

2025-09-09

Abstract excerpt

<title>Abstract</title> <p>Despite major technical advancements, the prediction of radiotherapy clinical outcome is a major challenge to radiation oncologists due to lack of suitable predictive biomarkers. To address this, a radio-resistant cell line (RR) has been generated from A549 cells (CC) after fractionated doses followed by clonogenic assay. On evaluation these cells showed cancer stem like features. The t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 22cde341-721c-56e9-982f-1d3f46263ad5
DOI: 10.21203/rs.3.rs-7240316/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Analysis of Radio-resistant A549 Cells Identify Stemness Gene Signature to Predict Radiotherapy Response in Lung Adenocarcinoma PatientsDOI 10.21203/rs.3.rs-7240316/v1Read

Molecular mechanism of radiation tolerance in lung adenocarcinoma cells using single-cell RNA sequencing.Semantic proximity Read

A gene expression platform to predict benefit from adjuvant external beam radiation in resected non-small cell lung cancerSemantic proximity Read

Identification and exploration of key genes associated with radioresistance in lung adenocarcinomaSemantic proximity Read

Molecular mechanisms of tumor resistance to radiotherapySemantic proximity Read

Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analysesSemantic proximity Read

Radiotherapy diagnostic biomarkers in radioresistant human H460 lung cancer stem-like cellsSemantic proximity Read

Prediction of Response to Radiotherapy by Characterizing the Transcriptomic Features in Clinical Tumor Samples across 15 Cancer Types.Semantic proximity Read

A Radioresponse-Related lncRNA Biomarker Signature for Risk Classification and Prognosis Prediction in Non-Small-Cell Lung CancerSemantic proximity Read

RNA-Seq analysis of peripheral blood mononuclear cells reveals unique transcriptional signatures associated with radiotherapy response of nasopharyngeal carcinoma and prognosis of head and neck cancerSemantic proximity Read

Cervical cancer stem-like cell transcriptome profiles predict response to chemoradiotherapySemantic proximity Read

TGM2-Mediated Autophagy Contributes to the Radio-Resistance of Non-Small Cell Lung Cancer Stem-like CellsSemantic proximity Read

Factors and molecular mechanisms of radiation resistance in cancer cellsSemantic proximity Read