Article
von Willebrand factor: the complex molecular genetics of a multidomain and multifunctional protein.
Journal of thrombosis and haemostasis : JTH - 1 Jul 2011
Schneppenheim R, Budde U
Abstract excerpt
von Willebrand disease (VWD), the most common inherited bleeding disorder in humans, is characterised by a prolonged bleeding time due to quantitative and/or functional deficits of von Willebrand factor (VWF), a huge multimeric protein. Given the large size and complexity of the protein, the many functions of VWF, for example, binding to collagen, to platelet GPIb, and to FVIII, the localisation of these binding...
Topics
- Genetic Testing
- Humans
- Mutation
- Protein Conformation
- von Willebrand Diseases
- von Willebrand Factor