Article
Plac1 (placenta-specific 1) is essential for normal placental and embryonic development.
Molecular reproduction and development - 1 Aug 2012
Jackman Suzanne M, Kong Xiaoyuan, Fant Michael E
Abstract excerpt
Plac1 is a recently identified, X-linked gene whose expression is restricted primarily to cells of the trophoblast lineage. It localizes to a chromosomal locus previously implicated in placental growth. We therefore sought to determine if Plac1 is necessary for placental and embryonic development by examining a mutant mouse model. Plac1 ablation resulted in placentomegaly and mild intrauterine growth retardation...
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