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Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship.

Neuron - 11 Sept 2008

Kimura Ken-Ichi, Hachiya Tomoaki, Koganezawa Masayuki, Tazawa Tatsunori, Yamamoto Daisuke

Abstract excerpt

Biologists postulate that sexual dimorphism in the brain underlies gender differences in behavior, yet direct evidence for this has been sparse. We identified a male-specific, fruitless (fru)/doublesex (dsx)-coexpressing neuronal cluster, P1, in Drosophila. The artificial induction of a P1 clone in females effectively provokes male-typical behavior in such females even when the other parts of the brain are not...

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PMID: 18786359
DOI: 10.1016/j.neuron.2008.06.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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