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Article

Zebrafish diencephalic A11-related dopaminergic neurons share a conserved transcriptional network with neuroendocrine cell lineages.

Development (Cambridge, England) - 1 Mar 2009

Löhr Heiko, Ryu Soojin, Driever Wolfgang

Abstract excerpt

Vertebrate dopaminergic neurons develop in distinct neural territories to constitute one of the major neuromodulatory systems. We have identified a zebrafish mutation in the bHLH-PAS family member arnt2, based on a strong reduction in cell number of specific dopaminergic neuron groups in the hypothalamus and posterior tuberculum. Knockdown of sim1 causes a dopaminergic phenotype similar to arnt2 mutants,...

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PMID: 19234064
DOI: 10.1242/dev.033878

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