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Article

Red blood cell adhesion to heme‐activated endothelial cells reflects clinical phenotype in sickle cell disease

15 Jun 2018

Abstract excerpt

In sickle cell disease (SCD), 'disease severity' associates with increased RBC adhesion to quiescent endothelium, but the impact on activated endothelium is not known. Increased concentrations of free heme result from intravascular hemolysis in SCD. Heme is essential for aerobic metabolism, and plays an important role in numerous biological processes. Excess free heme induces reactive oxygen species generation...

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PMID: 29905377
DOI: 10.1002/ajh.25159

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