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ApoE - Functionalization of Nanoparticles for Targeted Brain Delivery - A Feasible Method for Polyplexes?

2023-08-22

Abstract excerpt

<title>Abstract</title> <p>The blood- brain barrier (BBB) poses a major obstacle in the treatment of all types of central nervous system (CNS) diseases. Small interfering RNA (siRNA) offers in principle a promising therapeutic approach by downregulating disease-related genes via RNA interference. However, the BBB is a formidable barrier for macromolecules such as nucleic acids. In an effort to develop a brain-tar...

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Literature Corpus work
227b1eaf-4263-5f24-a531-032253e07229
DOI
10.21203/rs.3.rs-3265897/v1
Open publication

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ApoE - Functionalization of Nanoparticles for Targeted Brain Delivery - A Feasible Method for Polyplexes?DOI 10.21203/rs.3.rs-3265897/v1
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