Article

Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer

2025-01-04

Abstract excerpt

<h4>Summary</h4> Postpartum mammary gland remodeling after a pregnancy/lactation cycle is characterized by mechanisms of immunosuppression. Here we show that SEMA7A promotes PD-L1 expression in immune cells of the mammary tissue during involution. These same phenotypes are mimicked in the microenvironment of SEMA7A-expressing tumors, which partially respond to αPD-1/αPD-L1 treatments in vivo. However, cells that...

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Literature Corpus work: 225a0d73-9671-5de2-bf17-4b273fd7c68f
DOI: 10.1101/2025.01.03.631229

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