The EGF-TM7 family: unusual structures at the leukocyte surface

Abstract excerpt

The isolation of cDNA clones encoding mouse F4/80, human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 1 (EMR1) and human CD97 has resulted in the description of a novel family of seven-transmembrane spanning cell surface molecules. These members of the EGF-TM7 family are characterized by a variable number of NH2-terminal EGF domains and seven transmembrane-spanning hydrophobic...

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