Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages

7 Apr 2016

Abstract excerpt

Accumulation of tumor-associated macrophages (TAM) correlates with malignant progression, immune suppression, and poor prognosis. In this study, we defined a critical role for the cell-surface guidance molecule SEMA3A in differential proliferative control of TAMs. Tumor cell-derived SEMA3A restricted the proliferation of protumoral M2 macrophages but increased the proliferation of antitumoral M1, acting through...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apelin-related biomedical research
Share to Axon Guidance and Neuronal Signaling
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27197153
DOI: 10.1158/0008-5472.can-15-2596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated MacrophagesPMID 27197153Read ↗

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cellsSemantic proximity Read ↗

Bioinformatic analysis of SEMA4D and its potential clinical value research in pan-cancerSemantic proximity Read ↗

cPLA2 Blockade Attenuates S100A7-Mediated Breast Tumorigenicity by Inhibiting the Immunosuppressive Tumor MicroenvironmentSemantic proximity Read ↗

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDACSemantic proximity Read ↗

Endostatin inhibits the growth and migration of 4T1 mouse breast cancer cells by skewing macrophage polarity toward the M1 phenotype.Semantic proximity Read ↗

Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC.Semantic proximity Read ↗

The emerging role of class-3 semaphorins and their neuropilin receptors in oncologySemantic proximity Read ↗

Hypoxia-induced Semaphorin 6B promotes the development of cervical cancer through regulating macrophage polarizationSemantic proximity Read ↗

Targeting Siglec-10/α3β1 Integrin Interactions Enhances Macrophage-Mediated Phagocytosis of Pancreatic CancerSemantic proximity Read ↗

SEMA3C Supports Pancreatic Cancer Progression by Regulating the Autophagy Process and Tumor Immune MicroenvironmentSemantic proximity Read ↗

Cancer cell phagocytosis induces an anti-inflammatory gene regulatory program in macrophagesSemantic proximity Read ↗

Semaphorin-7A promotes macrophage-mediated mammary epithelial and ductal carcinoma in situ invasionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.