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Article

Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.

Cell death & disease - 24 Sept 2021

Rutherford Taylor R, Elder Alan M, Lyons Traci R

Abstract excerpt

Semaphorin-7a (SEMA7A), best known as a neuroimmune molecule, plays a diverse role in many cellular processes and pathologies. Here, we show that SEMA7A promotes anoikis resistance in cultured mammary epithelial cells through integrins and activation of pro-survival kinase AKT, which led us to investigate a role for SEMA7A during postpartum mammary gland involution-a normal developmental process where cells die...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34561423
DOI: 10.1038/s41419-021-04133-5
PMCID: PMC8463677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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