Article

Molecular mechanism of ACAD9 in mitochondrial respiratory complex 1 assembly

2021-01-09

Abstract excerpt

ACAD9 belongs to the acyl-CoA dehydrogenase family, which catalyzes the α-β dehydrogenation of fatty acyl-CoA thioesters. Thus, it is involved in fatty acid β-oxidation (FAO). However, it is now known that the primary function of ACAD9 is as an essential chaperone for mitochondrial respiratory complex 1 assembly. ACAD9 interacts with ECSIT and NDUFAF1, forming the mitochondrial complex 1 assembly (MCIA) complex. A...

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Literature Corpus work: 223938da-c049-5f0e-9470-fb6424ea7d10
DOI: 10.1101/2021.01.07.425795

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