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Article

Impact of AbaI mutation on virulence, biofilm development, and antibiotic susceptibility in Acinetobacter baumannii.

Scientific reports - 14 Sept 2024

Pumirat Pornpan, Santajit Sirijan, Tunyong Witawat, Kong-Ngoen Thida, Tandhavanant Sarunporn, Lohitthai Sanisa, Rungruengkitkun Amporn, Chantratita Narisara, Ampawong Sumate, Reamtong Onrapak, Indrawattana Nitaya

Abstract excerpt

The quorum sensing (QS) system mediated by the abaI gene in Acinetobacter baumannii is crucial for various physiological and pathogenic processes. In this study, we constructed a stable markerless abaI knockout mutant (ΔabaI) strain using a pEXKm5-based allele replacement method to investigate the impact of abaI on A. baumannii. Proteomic analysis revealed significant alterations in protein expression between the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39277662
DOI: 10.1038/s41598-024-72740-1
PMCID: PMC11401864

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