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Mutant zebrafish lacking slc25a22a show spontaneous seizures and respond to the anti-seizure medication valproic acid.

Disease models & mechanisms - 1 Jun 2025

Lee So-Hyun, Liang Ting, Chandrasekaran Gopalakrishnan, Zhang Jun, Kim Seong Soon, Parvathi Sundareswaran Varier, Lee Seok Won, Cho Eun-Seo, Shin Hee-Young, Yoon Young-Gyu, Jo Jihoon, Bae Myung Ae, Choi Seok-Yong, Kim Myeong-Kyu

Abstract excerpt

Epilepsy is a neurological disorder associated with abnormal neuronal activity in the central nervous system, resulting in recurrent seizures. Various anti-seizure medications (ASMs) are effective against epilepsy. However, approximately one-third of patients still do not respond to currently available ASMs either alone or in combination because the etiology of their epilepsy remains unclear. To create a novel...

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Identifiers

PMID: 40539845
DOI: 10.1242/dmm.052275
PMCID: PMC12208195

Genes

SLC25A22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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