Article

Cenobamate as add-on treatment for<i>SCN8A</i>developmental and epileptic encephalopathy

2024-10-19

Abstract excerpt

<h4>Objectives</h4> Developmental and epileptic encephalopathies (DEEs) caused by pathogenic variants in SCN8A are associated with difficult-to-treat and early-onset seizures, developmental delay/intellectual disability, impaired quality of life, and increased risk of early mortality. Commonly used antiseizure medications (ASMs) for SCN8A- related disorders, caused by gain-of-function variants, are sodium channel...

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Literature Corpus work: c87298d8-c7cf-5dff-a4e3-d67475d9479f
DOI: 10.1101/2024.10.17.24312949

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