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Article

Structural basis of broad HIV neutralization by a vaccine-induced cow antibody

27 May 2020

Abstract excerpt

Potent broadly neutralizing antibodies (bnAbs) to HIV have been very challenging to elicit by vaccination in wild-type animals. Here, by x-ray crystallography, cryo-electron microscopy, and site-directed mutagenesis, we structurally and functionally elucidate the mode of binding of a potent bnAb (NC-Cow1) elicited in cows by immunization with the HIV envelope (Env) trimer BG505 SOSIP.664. The exceptionally long...

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PMID: 32518821
DOI: 10.1126/sciadv.aba0468

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