Article
Apolipoprotein E genotype-dependent nutrigenetic effects to prebiotic inulin for modulating systemic metabolism and neuroprotection in mice via gut-brain axis.
Nutritional neuroscience - 1 Aug 2022
Yanckello Lucille M, Hoffman Jared D, Chang Ya-Hsuan, Lin Penghui, Nehra Geetika, Chlipala George, McCulloch Scott D, Hammond Tyler C, Yackzan Andrew T, Lane Andrew N, Green Stefan J, Hartz Anika M S, Lin Ai-Ling
Abstract excerpt
OBJECTIVE: The goal of the study was to identify the potential nutrigenetic effects to inulin, a prebiotic fiber, in mice with different human apolipoprotein E (APOE) genetic variants. Specifically, we compared responses to inulin for the potential modulation of the systemic metabolism and neuroprotection via gut-brain axis in mice with human APOE ϵ3 and ϵ4 alleles. METHOD: We performed experiments with young...
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