Back to search

Article

Gut metabolite IPA alleviates white matter post-ICH injury by enhancing myelin debris phagocytosis via <i>Stap1</i> inhibition

2025-11-20

Abstract excerpt

<h4>Background</h4> Intracerebral hemorrhage (ICH) causes neurological dysfunction and white matter injury (WMI) characterized by myelin loss, axonal injury and myelin debris accumulation. Microglia-mediated debris clearance is critical for WMI repair. The microbiota-gut-brain axis plays an essential role in the central nervous system diseases, one of the ways in which gut microbiota affects brain is via producin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d13a5790-add9-5047-8662-a44713d74263
DOI
10.1101/2025.11.19.689382
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Gut metabolite IPA alleviates white matter post-ICH injury by enhancing myelin debris phagocytosis via <i>Stap1</i> inhibitionDOI 10.1101/2025.11.19.689382
Gut microbiota-derived indole-3-propionic acid preserves dorsal hippocampal catecholamines to prevent post-stroke cognitive impairmentSemantic proximity
Gut Microbiota Dysbiosis after Traumatic Brain Injury Contributes to Persistent Microglial Activation Associated with Upregulated Lyz2 and Shifted Tryptophan Metabolic Phenotype.Semantic proximity
Restoring a balanced pool of host-derived and microbiota-derived ligands of the aryl hydrocarbon receptor is beneficial after strokeSemantic proximity
Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: from change to potential therapeutic objectivesSemantic proximity
Multi-omics reveals specific host metabolism-microbiome associations in intracerebral hemorrhageSemantic proximity
Exploring the associations of gut microbiota with inflammatory and the early hematoma expansion in intracerebral hemorrhage: From variations to potential therapeutic targetsSemantic proximity
Modulation of Host Immunity by Microbiome‐Derived Indole‐3‐Propionic Acid and Other Bacterial MetabolitesSemantic proximity
The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injurySemantic proximity
Tryptophan-rich diet and its effects on brain Tregs in alleviating neuroinflammation and cognitive impairmentSemantic proximity
Influence of blood-brain barrier and intestinal barrier on microglial phenotypes: a perspective of clinical and prognostic implications.Semantic proximity
Elevated circulating levels of phenylacetylglutamine in stroke patients with T2D are linked to specific gut microbiotaSemantic proximity
Novel Insights Into Pathogenesis and Therapeutic Strategies of Hepatic Encephalopathy, From the Gut Microbiota PerspectiveSemantic proximity
Select a neighboring publication to make it the new centre.